We can't compare numbers whose final significant digits are set at different places. Because:

In this problem, 0.25 has two significant figures, 2 and 5. And the final significant digit, 5, is set at the hundredths place and considered accurate.

While, 0.250 has three significant figures, 2,5 and 0. And the final significant digit,0, is set at the thousandths place and considered accurate.

But we dont know how these two numbers measured. 0.25 could be 0.2499... rounded up to the nearest hundredth, or 0.2503 rounded down.

While, 0.250 could be 0.2498... rounded up to the nearest thousandth, or 0.2504... rounded down.

Therefore, the answer is: No, we can't compare them.